The use of 25(OH)D saliva test as a substitute for 25(OH)D serum test in healthy people

  • Dina Keumala Sari Faculty of Medicine, Universitas Sumatera Utara
  • Liza Meutia Sari Faculty of Dentistry, Universitas Syah Kuala
  • Lidya Imelda Laksmi Faculty of Medicine, Universitas Sumatera Utara
Keywords: vitamin D, 25(OH)D, saliva test

Abstract

Background and Objectives: Examination of serum 25(OH)D levels of vitamin D in the body circulation illustrates the level of circulating vitamin D, while serum 1.25(OH)D is used to describe vitamin D activity. Several studies have shown that there is a non-invasive test that can be done to check vitamin D levels, namely through salivary levels. This study aims to determine the ratio between serum 25(OH)D and 1.25(OH)D serum levels and to compare the levels in saliva.Methods: This study was a cross-sectional study that included 36 healthy people, male and female, aged 18-35 years old, living in Medan, North Sumatra. The tests performed were levels of 25(OH)D, 1.25(OH)D in serum and saliva.Results: The mean serum 25 (OH) D level was 17.22±4.37 ng/mL and the 25(OH)D saliva level was 3.46 ng/mL for the minimum value and 51.0 ng/mL for the maximum value (median: 6.01 ng/mL). The results showed a relationship between 25(OH)D saliva and serum 25(OH)D levels (p=0.04). There was no relationship between the levels of 1.25(OH)D in saliva and serum 1.25(OH)D.Conclusion: There was a relationship between 25(OH)D saliva and 25(OHD) serum levels in healthy people. Salivary 25(OH)D levels can be used as a non-invasive laboratory test compared to serum 25(OH)D levels.

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Author Biographies

Dina Keumala Sari, Faculty of Medicine, Universitas Sumatera Utara
Nutrition Department
Liza Meutia Sari, Faculty of Dentistry, Universitas Syah Kuala
Oral Medicine Department
Lidya Imelda Laksmi, Faculty of Medicine, Universitas Sumatera Utara
Anatomy-Pathology Department

Submitted

2020-10-27
Accepted
2020-10-27
Published
2020-10-27
Section
Articles