Plasma Folate, Vitamin B6 and B12 in Their Relationship to the Presence of Probiotic Strain Bifidobacterium animalis subsp. Lactis HNO19 (DR10TM) Among Indonesian Pregnant Women in Their Third Semester

  • Saptawati Bardosono Editor in Chief World Nutrition Journal Indonesian Nutrition Association http://orcid.org/0000-0002-4258-1750
  • Noroyono Wibowo Department of Obstetric and Gynaecology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo General Hospital
  • Luciana Budiati Sutanto Indonesian Nutrition Association
  • Rima Irwinda Department of Obstetric and Gynaecology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo General Hospital
  • Rebecca Cannan Fonterra Research and Development Centre
  • Angela Rowan Fonterra Research and Development Centre
  • James Dekker Fonterra Research and Development Centre
Keywords: Folate, Indonesia, pregnancy, probiotic DR10TM, vitamin B6, vitamin B12

Abstract

Introduction Vitamin B12 plays a role during pregnancy in maintaining folate metabolism. Together with folate and vitamin B6, B12 is involved as a coenzyme in DNA synthesis and various methylation reactions in developing embryos. This study aims to compare plasma folate, vitamin B6 and B12 blood levels with respect to the presence of probiotic strain Bifidobacterium animalis subsp. lactis HNO19 (DR10TM) among pregnant women in Indonesia. Methods: This study is part of a larger study entitled “Effects of Bifidobacterium animalis subsp. lactis HNO19 (DR10TM), inulin, and micronutrient fortified milk on fecal DR10TM, immune markers, and maternal micronutrients among Indonesian pregnant women.” Further analyses were performed using independent-t test or Mann Whitney test, GLM-repeated measures and chi-square test, to compare folate, vitamin B6 and B12 intake and blood concentration during pregnancy with presence (n=22) and absence (n=55) subjects of fecal DR10TM at third trimester. Results: At the first trimesters there was no difference in plasma vitamin B6 and vitamin B12 levels between the two groups, based on the presence or absence of fecal DR10TM. However, at the second and third trimester, vitamin B6 blood concentration (p=0.034 and p=0.001) and vitamin B12 blood concentrations at the third trimester (p=0.035) were significantly higher in the fecal DR10TM positive group, while having a similar vitamin B6 and B12 intake. Conclusion: Consumption of pre- and probiotics during the periconceptional period may be a useful strategy for improving maternal vitamin B’s vitamins, especially vitamin B6 and B12 status and therefore provide benefits for the offspring’s quality of life.

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References

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Sande, H. Van , Jacquemyn Y, Karepouan N, Ajaji M. Vitamin B12 in pregnancy: maternal and fetal/neonatal effectsA review. Open journal of obstetrics and gynecology. -Irvine, CA, 2011, currens 2013;3(7):599-602. [Google Scholar]

Sukumar N, Venkataraman H, Wilson S, Goljan I, Selvamoni S, Patel V, et al. Vitamin B12 status among pregnant women in the UK and its association with obesity and gestational diabetes. Nutrients 2016 Dec;8(12):768. [Google Scholar]

Barua S, Kuizon S, Ma aJ. Folic acid supplementation in pregnancy and implications in health and disease. J Biomed Sci 2014;21:77-85. Available from: http://www.jbiomedsci.com/content/21/1/77 [Google Scholar]

Ho CL, Quay TA, Devlin AM, Lamers Y. Prevalence and Predictors of Low Vitamin B6 Status in Healthy Young Adult Women in Metro Vancouver. Nutrients 2016 Sep;8(9):538. [Google Scholar]

Hunt A, Harrington D, and Robinson S . Vitamin B12 deficiency. BMJ 2014;349. doi: 10.1136/bmj.g5226. [Google Scholar]

Wibowo N, Bardosono S, and Irwinda R . Effects of Bifidobacterium animalis subsp. lactis HNO19 (DR10TM), inulin, and micronutrient fortified milk on fecal DR10TM, immune markers, and maternal micronutrients among Indonesian pregnant women. Asia Pac J Clin Nutr 2016;25(Suppl 1). [Google Scholar]

Eck P, Friel J. Should probiotics be considered as vitamin supplements. Gastroenterology 2013;138:789-91. [Google Scholar]

University TUN. Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food and Nutrition Bulletin 2008;29(2). [Google Scholar]

LeBlanc JG, Laino JE, Mj dV, Vannini V, Sinderen, D. van , Taranto MP, et al. B-group vitamin production by lactic acid bacteria – current knowledge and potential applications. J Appl Microb 2011;111:1297. [Google Scholar]

Eck P and Friel J. Vitamins & minerals. Vitam Miner 2013: e124. doi:10.4172/vms.1000e124

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Submitted

2018-12-03
Accepted
2018-12-03
Published
2019-01-04
Section
Articles

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